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Liver and cancer treatment: what you need to know now and for the future

Liver cancer can be one of the most difficult cancers to treat, especially when diagnosed late. In this article, we explain available treatment options, what influences outcomes, and how cryopreservation may offer future-facing hope when modern medicine reaches its limits.
4 minutes
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Liver cancer
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April 17 2025
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Cancer
Alessia Casali

Understanding liver cancer

Liver cancer, also called hepatic cancer, is a condition where malignant cells grow in the tissues of the liver. It may be:

  • Primary liver cancer, which starts in the liver itself (e.g., hepatocellular carcinoma)
  • Secondary (metastatic) liver cancer, which starts elsewhere and spreads to the liver (commonly from colorectal, breast, or pancreatic cancer)

According to the World Health Organization, liver cancer is among the top causes of cancer-related deaths worldwide, largely due to its aggressive nature and late detection.

What makes liver cancer difficult to treat?

Liver cancer presents unique challenges:

  • Late diagnosis: Symptoms often appear only in later stages
  • Liver function: Many patients already have chronic liver disease or cirrhosis, which limits treatment options
  • Resistance: Some tumors are less responsive to chemotherapy or radiotherapy
  • High recurrence rates: Even after initial treatment, liver cancer often returns

Because of this, early and accurate diagnosis followed by a tailored treatment plan is essential.

Symptoms to watch for

Common symptoms of liver cancer include:

  • Pain in the upper right abdomen
  • Unexplained weight loss
  • Loss of appetite
  • Fatigue or weakness
  • Jaundice (yellowing of the skin and eyes)
  • Swelling in the abdomen (ascites)

If you experience any of these symptoms, especially if you have a history of hepatitis or liver disease, prompt medical evaluation is crucial.

Diagnosing liver cancer

Liver cancer diagnosis involves:

  • Blood tests (including alpha-fetoprotein or AFP levels)
  • Imaging (ultrasound, CT scan, or MRI)
  • Biopsy, if needed, to confirm the cancer type
  • Liver function tests, to assess how much healthy liver tissue remains

This combination helps determine the stage and guide treatment.

Liver and cancer treatment options

The best treatment for liver cancer depends on the type, size, location, and stage of the tumor, as well as the patient's overall liver function and health. Options include:

1. Surgical resection

If the tumor is localized and the liver is otherwise healthy, surgical removal (resection) offers the best chance of cure.

  • Best for small, early-stage tumors
  • Requires good liver function
  • Risks include bleeding and infection

2. Liver transplant

For patients with advanced liver disease or multiple tumors, a liver transplant can treat both cancer and underlying cirrhosis.

  • Strict criteria apply (tumor size, number, spread)
  • Requires availability of a donor organ
  • High success rates in carefully selected patients

3. Ablation therapies

These methods destroy tumors without surgery:

  • Radiofrequency ablation (RFA) uses heat
  • Microwave ablation uses electromagnetic waves
  • Cryoablation uses extreme cold
  • Ethanol injection (less common today)

These are often used when surgery isn’t an option or as a bridge to transplant.

4. Transarterial therapies

The liver has a unique blood supply, allowing targeted treatments:

  • Transarterial chemoembolization (TACE): Delivers chemo directly into the tumor's blood supply and blocks it
  • Transarterial radioembolization (TARE): Uses radioactive beads

These help slow tumor growth and relieve symptoms, but are not curative.

5. Systemic treatments

When liver cancer spreads or can't be surgically treated, systemic therapies are used:

  • Targeted therapies like sorafenib or lenvatinib
  • Immunotherapy, such as immune checkpoint inhibitors
  • Chemotherapy, though less effective in liver cancer

Ongoing clinical trials are exploring combinations of these drugs to improve survival.

Can liver cancer be cured?

Early-stage liver cancer can sometimes be cured with surgery or transplantation, but most patients are diagnosed too late for curative treatment. In these cases, the goal becomes managing symptoms, slowing progression, and maintaining quality of life.

The overall 5-year survival rate for liver cancer is around 20%, but this varies widely based on:

  • Stage at diagnosis
  • Treatment access
  • Underlying liver function
  • General health and response to therapy

What if treatment fails?

When treatment fails, many patients and families face incredibly difficult decisions. At this point, traditional medicine focuses on comfort and quality of life through palliative care.

But for those who want to preserve the possibility of life beyond today’s limits, cryopreservation is becoming an option worth considering.

How cryopreservation connects to liver and cancer treatment

Cryopreservation is not a cure for liver cancer. But for patients facing terminal progression, especially when curative treatments are exhausted, cryopreservation offers a scientifically grounded way to preserve the body or brain in hopes that future technology may offer new solutions.

Imagine a future where:

  • Organ regeneration is routine
  • Cancer cells can be removed at the molecular level
  • Damaged livers can be repaired with bioprinting or gene editing

Cryonics can serve as a bridge to that future, preserving patients at ultra-low temperatures until revival is theoretically possible.

How it works at Tomorrow.bio

At Tomorrow.bio, we provide:

  • Whole-body and brain-only cryopreservation plans
  • 24/7 standby teams to ensure rapid intervention after legal death
  • On-site stabilization and perfusion to minimize damage
  • Long-term storage in advanced facilities across Europe

Most patients fund cryopreservation through life insurance, making it financially accessible.

Is cryopreservation right for me?

Cryopreservation is a deeply personal decision. It may be right for you if:

  • You’ve been diagnosed with late-stage or terminal liver cancer
  • You’ve exhausted current medical options
  • You believe in the potential of future science and regenerative medicine
  • You want to take control over your own death and future possibilities

It’s not about clinging to life—it’s about preserving the option to continue it when medicine catches up.

Explore more from Tomorrow.bio

About Tomorrow.bio

At Tomorrow.bio, we are dedicated to advancing the science of cryopreservation with the goal of giving people a second chance at life. As Europe’s leading human cryopreservation provider, we focus on rapid, high-quality standby, stabilization, and storage of terminal patients — preserving them until future medical technologies may allow revival and treatment.

Our mission is to make human cryopreservation a reliable and accessible option for everyone. We believe that no life should end because current medical capabilities fall short.

Our vision is a future where death is optional — where people have the freedom to choose long-term preservation in the face of terminal illness or fatal injury, and to awaken when medicine has caught up.

Interested in learning more or becoming a member?
📧 Contact us at: hello@tomorrow.bio
🌐 Visit our website: www.tomorrow.bio
🤝 Schedule a call with our team: Book a call